The impact of orbitofrontal dysfunction on cocaine addiction

Citation:

Lucantonio, F., Stalnaker, T. A., Shaham, Y., Niv, Y., & Schoenbaum, G. (2012). The impact of orbitofrontal dysfunction on cocaine addiction. Nature Neuroscience , 15 (3), 358–366.

ISSN:

10976256

ISBN Number:

1097-6256

Abstract:

Cocaine addiction is characterized by poor judgment and maladaptive decision-making. Here we review evidence implicating the orbitofrontal cortex in such behavior. This evidence suggests that cocaine-induced changes in orbitofrontal cortex disrupt the representation of states and transition functions that form the basis of flexible and adaptive 'model-based' behavioral control. By impairing this function, cocaine exposure leads to an overemphasis on less flexible, maladaptive 'model-free' control systems. We propose that such an effect accounts for the complex pattern of maladaptive behaviors associated with cocaine addiction.

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DOI:

10.1038/nn.3014
Last updated on 12/11/2019